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Angioedema, severe congestive heart failure (CHF), surgery or anesthesia, volume depletion (consider lower dosage) Coadministration with m TOR inhibitors (eg, temsirolimus) may increased risk for angioedema Risk of hypotension, especially in patients with volume or salt depletion secondary to salt restriction or prolonged diuretic treatment Risk of hyperkalemia Use with caution in renal artery stenosis; avoid in bilateral renal artery stenosis Renal impairment reported Intestinal problems (ie, sprue-like enteropathy) reported; symptoms may include severe, chronic diarrhea with substantial weht loss Dual blockade of the renin-angiotensin system with angiotensin-receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, or aliskiren is associated with increased risk of hypotension, hyperkalemia, and altered renal function (including acute renal failure) in comparison with monotherapy; closely monitor blood pressure Children The above information is provided for general informational and educational purposes only.

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